Effects of cocaine- and amphetamine-regulated transcript peptide, leptin and orexins on hypothalamic serotonin release

被引：32

作者：

Orlando, G ^{[1
]}

Brunetti, L ^{[1
]}

Di Nisio, C ^{[1
]}

Michelotto, B ^{[1
]}

Recinella, L ^{[1
]}

Ciabattoni, G ^{[1
]}

Vacca, M ^{[1
]}

机构：

[1] Univ G DAnnunzio, Sch Pharm, Dept Sci Farm, I-66013 Chieti, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 430卷 / 2-3期

关键词：

CART (cocaine- and amphetamine-regulated transcript); leptin; orexin; fenfluramine; hypothalamus; 5-HT; (5-hydroxytryptamine; serotonin);

D O I：

10.1016/S0014-2999(01)01380-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have studied the effects of cocaine- and amphetamine-regulated transcript (CART) peptide-(55-102), leptin, orexin-A and orexin-B on basal and depolarization (K+ 15 mW)-induced serotonin (5-hydroxytryptamine, 5-HT) release from rat hypothalamic neuronal endings (synaptosomes) in vitro. We have found that leptin and CART peptide-(55-102) have no effect on 5-HT release, while orexin-A and orexin-B inhibit depolarization-stimulated serotonin release. We can conclude that leptin and CART peptide-(55-102), which play a physiological role as feeding inhibitors, do not acutely affect 5-HT release from hypothalamic synaptosomes; on the other hand, feeding induced by orexin-A and orexin-B could be partially explained by decreased 5-HT release. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：269 / 272

页数：4

共 23 条

[1] Leptin enters the brain by a saturable system independent of insulin [J].

Banks, WA ;

Kastin, AJ ;

Huang, WT ;

Jaspan, JB ;

Maness, LM .

PEPTIDES, 1996, 17 (02) :305-311

[2] Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat [J].

Brown, RE ;

Sergeeva, O ;

Eriksson, KS ;

Haas, HL .

NEUROPHARMACOLOGY, 2001, 40 (03) :457-459

[3] Cocaine- and amphetamine-regulated transcript peptide-(55-102) and thyrotropin releasing hormone inhibit hypothalamic dopamine release [J].

Brunetti, L ;

Orlando, G ;

Michelotto, B ;

Recinella, L ;

Vacca, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 409 (02) :103-107

[4] Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings [J].

Brunetti, L ;

Michelotto, B ;

Orlando, G ;

Vacca, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 372 (03) :237-240

[5] Leptin stimulates prostaglandin E2 and F2α, but not nitric oxide production in neonatal rat hypothalamus [J].

Brunetti, L ;

Orlando, G ;

Michelotto, B ;

Ragazzoni, E ;

Vacca, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 369 (03) :299-304

[6] Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis [J].

Calapi, G ;

Corica, F ;

Corsonello, A ;

Sautebin, L ;

Di Rosa, M ;

Campo, GM ;

Buemi, M ;

Mauro, VN ;

Caputi, AP .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (07) :975-982

[7] Intracerebroventricular infusion of leptin decreases serotonin transporter binding sites in the frontal cortex of the rat [J].

Charnay, Y ;

Cusin, I ;

Vallet, PG ;

Muzzin, P ;

Rohner-Jeanrenaud, F ;

Bouras, C .

NEUROSCIENCE LETTERS, 2000, 283 (02) :89-92

[8] Dexfenfluramine - An updated review of its therapeutic use in the management of obesity [J].

Davis, R ;

Faulds, D .

DRUGS, 1996, 52 (05) :696-724

[9]

Håkansson ML, 1998, J NEUROSCI, V18, P559

[10] Evidence that NPYY1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats [J].

Jain, MR ;

Horvath, TL ;

Kalra, PS ;

Kalra, SP .

REGULATORY PEPTIDES, 2000, 87 (1-3) :19-24

← 1 2 3 →