Effect of exercise training, selenium and vitamin E on some free radical scavengers in horses (Equus caballus)

被引:86
作者
Avellini, L [1 ]
Chiaradia, E [1 ]
Gaiti, A [1 ]
机构
[1] Univ Perugia, Ist Biochim & Chim Med, I-06122 Perugia, Italy
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1999年 / 123卷 / 02期
关键词
exercise; free radicals; GSH-Px; horse; malondialdehyde; peroxidative damage; training and nutrition; TRAP; vitamin E and selenium;
D O I
10.1016/S0305-0491(99)00045-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Physical exercise increases both tissue needs for oxygen and cellular respiration and causes an overproduction of free radicals. When free radical generation exceeds the cell's antioxidant capacity tissue-damage develops due to oxidative stress. Therefore, it appears important to increase the scavenger ability of the tissues. Controlled training and dietary supplements may provide ways of doing this. As a model, we used 3-year-old racehorses (Equus caballus) which underwent a series of different physical exercise trials before and after 70 days of daily training and dietary supplements (vitamin E and selenium). The above treatments were able to increase both red blood cell resistance to the peroxidative stress induced in vitro and the glutathione peroxidase activity in lymphocytes. Moreover, they were also able to decrease malondialdehyde (MDA) concentration in the plasma as well as vitamin E consumption and the mobilisation of low molecular weight antioxidants (total peroxyl-radical trapping) following the physical exercise trials. The results obtained indicated that the training and diet supplements we used were able to significantly increase horse antioxidant defences in both the extracellular fluids and blood cells of our horses, thus decreasing peroxidative phenomena following physical exercise. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:147 / 154
页数:8
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