Role of Interleukin 23 Signaling in Clostridium difficile Colitis

被引：70

作者：

Buonomo, Erica L. ^{[1
]}

Madan, Rajat ^{[2
]}

Pramoonjago, Patcharin ^{[3
]}

Li, Li ^{[2
]}

Okusa, Mark D. ^{[2
]}

Petri, William A., Jr. ^{[1
,2
,3
]}

机构：

[1] Univ Virginia, Dept Microbiol Immunol & Canc, Charlottesville, VA USA

[2] Univ Virginia, Dept Med, Charlottesville, VA USA

[3] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Clostridium difficile; colitis; interleukin 23 (IL-23); Th17; cytokines; enteric; Interleukin-10; lamina propria; nosocomial; mucosal immunity; CROHNS-DISEASE; T-CELLS; INFLAMMATION; IL-23; PATHOLOGY; SYSTEM; DRIVES; IL-17; MODEL;

D O I：

10.1093/infdis/jit277

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Clostridium difficile is currently the leading cause of hospital-acquired infections in the United States. Here, we observed increased interleukin 23 (IL-23) protein levels in human colon biopsy specimens positive for C. difficile toxins, compared with levels in negative controls (P=.008) We also investigated the role of IL-23 during C. difficile infection, using 2 distinct murine models. Mice lacking IL-23 signaling had a significant increase in survival (100% [12 mice]), compared with control mice (16.7%-50% [12 mice]). These data suggest a new potential drug target for human C. difficile treatment and indicate the first link between IL-23 and disease severity during murine infection.

引用

页码：917 / 920

页数：4

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