Functional Specialization of Interleukin-17 Family Members

被引：1223

作者：

Iwakura, Yoichiro ^{[1
,5
]}

Ishigame, Harumichi ^{[2
]}

Saijo, Shinobu ^{[3
]}

Nakae, Susumu ^{[4
]}

机构：

[1] Univ Tokyo, Ctr Expt Med & Syst Biol, Inst Med Sci, Lab Mol Pathogenesis,Minato Ku, Tokyo 1088639, Japan

[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[3] Chiba Univ, Med Mycol Res Ctr, Dept Mol Immunol, Chuo Ku, Chiba 2608673, Japan

[4] Univ Tokyo, Inst Med Sci, Frontier Res Initiat, Minato Ku, Tokyo 1088639, Japan

[5] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

IMMUNITY | 2011年 / 34卷 / 02期

关键词：

COLLAGEN-INDUCED ARTHRITIS; DELTA-T-CELLS; TH17; CELLS; HOST-DEFENSE; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; DIFFERENTIAL EXPRESSION; IL-17; CONTRIBUTES; INNATE PRODUCTION;

D O I：

10.1016/j.immuni.2011.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defenses against bacterial and fungal infections, whereas IL-17F is mainly involved in mucosal host defense mechanisms. IL-17E (IL-25) is an amplifier of Th2 immune responses. The functions of IL-17B, IL-17C, and IL-17D remain largely elusive. In this review, we describe the identified functions of each IL-17 family member and discuss the potential of these molecules as therapeutic targets.

引用

页码：149 / 162

页数：14

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