Optimizing magnetic nanoparticle design for nanothermotherapy

被引：206

作者：

Gazeau, Florence ^{[1
]}

Levy, Michael ^{[1
]}

Wilhelm, Claire ^{[1
]}

机构：

[1] Univ Paris Diderot, Lab Mat & Syst Complexes MSC, CNRS, UMR 7057, F-75205 Paris 13, France

来源：

NANOMEDICINE | 2008年 / 3卷 / 06期

关键词：

cancer; hyperthermia; magnetic nanoparticles; magnetism; targeting;

D O I：

10.2217/17435889.3.6.831

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Current developments in nanotechnology offer new tools to the design of nanometric heat-generating 'foci' that can be activated remotely by an external alternating magnetic field. These nanometric heat sources may serve for therapeutic hyperthermia alone or combined with other therapeutic modalities, such as drug delivery or gene therapy. Activable therapeutic tools at the nanoscale fulfill the requirements of future medicine in terms of spatial targeting and temporal control of therapy. The present review discusses fundamental aspects regarding the design of magnetic nanoparticles with optimized properties, by unraveling physical mechanisms that govern heating power in biological media. Towards therapy, achievements and promises of magnetic nanoparticles for cancer-localized hyperthermia, targeting strategies and multivalent functionalities are exposed.

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页码：831 / 844

页数：14

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