Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain

被引:222
作者
Narita, N
Hashimoto, K
Tomitaka, S
Minabe, Y
机构
[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV CORT FUNCT DISORDERS,KODAIRA,TOKYO 187,JAPAN
[2] NCNP,NIMH,DIV DRUG DEPENDENCE & PSYCHOTROP CLIN RES,ICHIKAWA,CHIBA 272,JAPAN
关键词
5-HT; (5-hydroxytryptamine; serotonin) reuptake inhibitor; sigma receptor; subtype; binding; brain; rat;
D O I
10.1016/0014-2999(96)00254-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The interactions of selective serotonin reuptake inhibitors and tricyclic antidepressants with subtypes of a receptors were investigated. The rank order of affinity (K-i values) from competition experiments of [H-3](+)-pentazocine binding to sigma(1) sites was: fluvoxamine > sertraline > S(+)-fluoxetine > (+)-fluoxetine > citalopram > imipramine > paroxetine > desipramine > R(-)-fluoxetine > (+/-)-norfluoxetine. The K-i values of all drugs for sigma(2) sites were more than 1000 nM. Furthermore, all drugs were more potent at sigma(1) sites than at sigma(2) sites. These findings suggest that sigma receptors (sigma(1) site) may play, in some way, a role in the actions of selective serotonin reuptake inhibitors.
引用
收藏
页码:117 / 119
页数:3
相关论文
共 14 条
[1]   CURRENT ADVANCES AND TRENDS IN THE TREATMENT OF DEPRESSION [J].
BLIER, P ;
DEMONTIGNY, C .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (07) :220-226
[2]  
Bowen Wayne D., 1993, Molecular Neuropharmacology, V3, P117
[3]   SEROTONIN, SCHIZOPHRENIA AND ANTIPSYCHOTIC DRUG-ACTION [J].
BREIER, A .
SCHIZOPHRENIA RESEARCH, 1995, 14 (03) :187-202
[4]  
FULLER RW, 1992, J CLIN PSYCHIAT, V53, P36
[5]  
GOFF DC, 1990, AM J PSYCHIAT, V147, P492
[6]   INTERACTIONS OF ERYTHRO-IFENPRODIL, THREO-IFENPRODIL, ERYTHRO-IODOIFENPRODIL, AND ELIPRODIL WITH SUBTYPES OF SIGMA-RECEPTORS [J].
HASHIMOTO, K ;
LONDON, ED .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 273 (03) :307-310
[7]  
NARITA N, 1995, SOC NEUR ABSTR, V25
[8]   A PROPOSAL FOR THE CLASSIFICATION OF SIGMA BINDING-SITES [J].
QUIRION, R ;
BOWEN, WD ;
ITZHAK, Y ;
JUNIEN, JL ;
MUSACCHIO, JM ;
ROTHMAN, RB ;
SU, TP ;
TAM, SW ;
TAYLOR, DP .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (03) :85-86
[9]   SERTRALINE POTENTLY DISPLACES (+)-[H-3]3-PPP BINDING TO SIGMA-SITES IN RAT-BRAIN [J].
SCHMIDT, A ;
LEBEL, L ;
KOE, BK ;
SEEGER, T ;
HEYM, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 165 (2-3) :335-336
[10]  
SHIRAYAMA Y, 1993, EUR J PHARMACOL, V37, P117