Leader of the pack: gene mapping in dogs and other model organisms

被引：205

作者：

Karlsson, Elinor K. ^{[1
,2
,3
]}

Lindblad-Toh, Kerstin ^{[1
,2
,4
]}

机构：

[1] Broad Inst Harvard, Cambridge, MA 02142 USA

[2] MIT, Cambridge, MA 02142 USA

[3] Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA

[4] Uppsala Univ, Dept Med Biochem & Microbiol, S-75124 Uppsala, Sweden

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 09期

关键词：

D O I：

10.1038/nrg2382

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. We share many diseases with our canine companions, including cancer, diabetes and epilepsy, making the dog an ideal model organism for comparative disease genetics. Using newly developed resources, whole-genome association in dog breeds is proving to be exceptionally powerful. Here, we review the different trait-mapping strategies, some key biological findings emerging from recent studies and the implications for human health. We also discuss the development of similar resources for other vertebrate organisms.

引用

页码：713 / 725

页数：13

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