Recombinant Canine Coronaviruses Related to Transmissible Gastroenteritis Virus of Swine Are Circulating in Dogs

被引：130

作者：

Decaro, Nicola ^{[1
]}

Mari, Viviana ^{[1
]}

Campolo, Marco ^{[1
]}

Lorusso, Alessio ^{[1
]}

Camero, Michele ^{[1
]}

Elia, Gabriella ^{[1
]}

Martella, Vito ^{[1
]}

Cordioli, Paolo ^{[2
]}

Enjuanes, Luis ^{[3
]}

Buonavoglia, Canio ^{[1
]}

机构：

[1] Fac Vet Med Bari, Dept Publ Hlth & Anim Sci, I-70010 Bari, Italy

[2] Ist Zooprofilatt Sperimentale Lombardia Emilia Ro, I-25124 Brescia, Italy

[3] Campus Univ Autonoma, Dept Mol & Cell Biol, Ctr Nacl Biotecnol, Madrid, Spain

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 03期

关键词：

SUBGENOMIC RNA-SYNTHESIS; BINDER PROBE TECHNOLOGY; TIME PCR ASSAY; MOLECULAR CHARACTERIZATION; PARVOVIRUS TYPE-2; FIELD STRAINS; GLYCOPROTEIN; QUANTITATION; INFECTION;

D O I：

10.1128/JVI.01937-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.

引用

页码：15332 / 1537

页数：6

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