Tandem mass spectrometry in quadrupole ion trap and ion cyclotron resonance mass spectrometers

被引：23

作者：

Payne, AH ^{[1
]}

Glish, GL ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

BIOLOGICAL MASS SPECTROMETRY | 2005年 / 402卷

关键词：

D O I：

10.1016/S0076-6879(05)02004-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Instruments that trap ions in a magnetic and/or electric field play a very important role in the analysis of biomolecules. The two predominant instruments in the category of trapping instrument are the quadrupole ion trap mass spectrometer (QIT-MS) and the ion cyclotron resonance (ICR) MS. The latter is also commonly called Fourier transform MS (FF-MS). The QIT is an inexpensive, simple, and rugged MS used for various routine applications. The ICR-MS is an expensive, high-performance instrument with figures of merit for resolution and mass accuracy surpassing all other mass spectrometers. This chapter covers the basic principles of operation of these instruments, including the trapping/manipulation/detection of ions and various approaches used to activate ions to perform tandem mass spectrometry experiments.

引用

页码：109 / 148

页数：40

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