latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant

被引：94

作者：

Pinto, S

Quintana, DG

Smith, P

Mihalek, RM

Hou, ZH

Boynton, S

Jones, CJ

Hendricks, M

Velinzon, K

Wohlschlegel, JA

Austin, RJ

Lane, WS

Tully, T

Dutta, A

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Cornell Univ, Joan & Sanford I Weill Grad Sch Med Sci, Grad Program Neurosci, New York, NY 10021 USA

[3] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

[5] Brandeis Univ, Dept Biol, Waltham, MA 02254 USA

[6] MIT, Dept Biol, Cambridge, MA 02139 USA

[7] Harvard Univ, Harvard Microchem Facil, Cambridge, MA 02138 USA

来源：

NEURON | 1999年 / 23卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(00)80752-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Drosophila latheo (lat) gene was identified in a behavioral screen for olfactory memory mutants. The original hypomorphic lat(P1) mutant (Boynton and Tully, 1992) shows a structural defect in adult brain. Homozygous lethal lat mutants lack imaginal discs, show little cell proliferation in the CNS of third instar larvae, and die as early pupae. lat(P1) was cloned, and all of the above mentioned defects of hypomorphic or homozygous lethal lat mutants were rescued with a lat(+) transgene. lat encodes a novel protein with homology to a subunit of the origin recognition complex (ORC). Human and Drosophila LAT both associate with ORC2 and are related to yeast ORC3, suggesting that LAT functions in DNA replication during cell proliferation.

引用

页码：45 / 54

页数：10

共 53 条

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