Microwave-Assisted Parallel Synthesis of Fused Heterocycles in a Novel Parallel Multimode Reactor

被引：45

作者：

Treu, Matthias ^{[2
]}

Karner, Thomas ^{[2
]}

Kousek, Roland ^{[2
]}

Berger, Helmut ^{[2
]}

Mayer, Moriz ^{[2
]}

McConnell, Darryl B. ^{[2
]}

Stadler, Alexander ^{[1
]}

机构：

[1] Anton Paar GnzbH, A-8054 Graz, Austria

[2] Boehringer Ingelheim Austria GmbH, A-1121 Vienna, Austria

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 06期

关键词：

D O I：

10.1021/cc800081b

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

New rotor types using disposable glass vials for small-scale parallel synthesis in multimode microwave reactors are introduced. One rotor comprises 16 groups of four vials, whereas the second uses four silicon carbide plates with a 6 x 4 matrix to process the vials. Both rotors achieve utmost temperature homogeneity upon microwave irradiation and can be used for microwave-mediated reactions at temperatures of up to 200 degrees C and pressures of 20 bar. The generation of three different heterocycle libraries furnishing thiophenes, oxindoles, and benzimidazoles using the new rotor types is described.

引用

页码：863 / 868

页数：6

共 64 条

[1] An improved synthesis of substituted benzolblthiophenes using microwave irradiation [J].