Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

被引：251

作者：

Zuñiga, R

Lucchetti, A

Galvan, P

Sanchez, S

Sanchez, C

Hernandez, A

Sanchez, H

Frahm, N

Linde, CH

Hewitt, HS

Hildebrand, W

Altfeld, M

Allen, TM

Walker, BD

Korber, BT

Leitner, T

Sanchez, J

Brander, C

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA

[2] Asociac Civil IMPACTA Salud & Educ, Lima, Peru

[3] Univ Oklahoma, Norman, OK 73019 USA

[4] Los Alamos Natl Lab, Los Alamos, NM USA

[5] Santa Fe Inst, Santa Fe, NM 87501 USA

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 06期

关键词：

D O I：

10.1128/JVI.80.6.3122-3125.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in the control of human immunodeficiency virus (HIV) disease progression exist. We present data generated from a Peruvian cohort of untreated, clade B-infected subjects, demonstrating that the proportion of Gag-specific, and in particular p24-reactive, CTL responses among the total virus-specific CTL activity is associated with individuals' CD4 counts and viral loads. Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development.

引用

页码：3122 / 3125

页数：4

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