Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity

被引:44
作者
Chandler, Angela L. [1 ]
Hobbs, Charlotte A. [1 ]
Mosley, Bridget S. [1 ]
Berry, Robert J. [2 ]
Canfield, Mark A. [3 ]
Qi, Yan Ping [2 ]
Siega-Riz, Anna Maria [4 ,5 ]
Shaw, Gary M. [6 ]
机构
[1] Univ Arkansas Med Sci Hosp, Dept Pediat, Coll Med, Arkansas Childrens Hosp Res Inst, Little Rock, AR 72202 USA
[2] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA
[3] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA
[4] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA
[5] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA
[6] Stanford Univ, Sch Med, Dept Pediat, Div Neonatal & Dev Med, Palo Alto, CA 94304 USA
基金
美国国家卫生研究院;
关键词
dietary periconceptional micronutrients; maternal nutrition; National Birth Defects Prevention Study; neural tube defects; one-carbon metabolism; FOLIC-ACID; BIRTH-DEFECTS; SPINA-BIFIDA; DIETARY-INTAKE; UNITED-STATES; RISK-FACTOR; OBESITY; FOLATE; HOMOCYSTEINE; PREVALENCE;
D O I
10.1002/bdra.23068
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
BACKGROUND Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs. The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity. METHODS Using data from the National Birth Defects Prevention Study, 19972005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake. RESULTS Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida. CONCLUSION In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence. Birth Defects Research (Part A) 2012. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码:864 / 874
页数:11
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