Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation

被引：21

作者：

Abdoul-Azize, Souleymane ^{[1
,2
]}

Bendahmane, Malika

Hichami, Aziz ^{[1
]}

Dramane, Gado ^{[1
,3
]}

Simonin, Anne-Marie ^{[1
]}

Benammar, Chahid

Sadou, Hassimi ^{[2
]}

Akpona, Simon ^{[3
]}

El Boustani, Es-Saddik ^{[4
]}

Khan, Naim A. ^{[1
]}

机构：

[1] Univ Bourgogne, INSERM, U866, Dijon, France

[2] Univ Abdou Moumouni, Lab Nutr, Niamey, Niger

[3] Univ Parakou, Lab Biochim, Parakou, Benin

[4] Univ Cadi Ayyad, Lab Nutr Sante, Marrakech, Morocco

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2013年 / 15卷 / 02期

关键词：

Zizyphus lotus L. (Desf.) polyphenols; Jurkat T-cells; Intracellular pH; Calcium; IL-2; Cell cycle; GREEN TEA POLYPHENOLS; T-CELLS; CYCLOPEPTIDE ALKALOIDS; ANALGESIC ACTIVITIES; ANTIOXIDANT ACTIVITY; PLANT POLYPHENOLS; IMMUNE FUNCTION; CALCIUM; ACID; LYMPHOCYTES;

D O I：

10.1016/j.intimp.2012.11.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We assessed the effects of Zizyphus lotus L (DesE) polyphenols (ZLP) on T-cell signaling and proliferation. Our results showed that ZLP exerted no effect on the increases in intracellular free calcium concentrations, [Ca2+](i), in human Jurkat T-cells. However, ZLP modulated the thapsigargin-induced increases in [Ca2+](i) in these cells. ZLP treatment was found to decrease the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). In addition, ZLP induced a rapid (t(1/2) = 33 s) and dose-dependent decrease in intracellular pH (pH(i)) in human Jurkat T-cells. Furthermore, ZLP significantly curtailed T-cell proliferation by diminishing their progression from S to G2/M phase of cell cycle, and the expression of interleukin-2 (IL-2) mRNA. Taken together, the results of the present study demonstrate that ZLP modulate cell signaling and exert immunosuppressive effects in human T-cells. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：364 / 371

页数：8

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