Complex networks orchestrate epithelial-mesenchymal transitions

被引：3259

作者：

Thiery, JP

Sleeman, JP

机构：

[1] CNRS, UMR 144, F-75248 Paris 05, France

[2] Inst Curie, F-75248 Paris, France

[3] Forschungszentrum Karlsruhe, Inst Genet & Toxikol, D-76021 Karlsruhe, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 02期

关键词：

D O I：

10.1038/nrm1835

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.

引用

收藏

页码：131 / 142

页数：12

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