Anion Channels: Regulation of CIC-3 by an Orphan Second Messenger

被引：12

作者：

Alekov, Alexi K. ^{[1
]}

Fahlke, Christoph ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Inst Neurophysiol, Hannover, Germany

[2] Zentrum Syst Neurowissensch, Hannover, ZSN, Germany

来源：

CURRENT BIOLOGY | 2008年 / 18卷 / 22期

关键词：

D O I：

10.1016/j.cub.2008.09.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CIC-3 is a ubiquitously expressed chloride channel isoform whose biological function has been a matter of debate for many years. A recent study reporting its regulation by Ins(3,4,5,6)P(4) assigns novel transport functions and cellular roles to CIC-3 and identifies a regulatory pathway that affects epithelial transport and endosomal pH regulation.

引用

页码：R1061 / R1064

页数：4

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