Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury

被引：21

作者：

Aubrecht, Jiri ^{[1
]}

Schomaker, Shelli J. ^{[1
]}

Amacher, David E. ^{[2
]}

机构：

[1] Pfizer Inc, Drug Safety R&D, Groton, CT 06340 USA

[2] Toxadvisor Toxicol Consulting, Hadlyme, CT USA

来源：

GENOME MEDICINE | 2013年 / 5卷

关键词：

CELL-DEATH; RISK;

D O I：

10.1186/gm489

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Biomarkers of drug-induced liver injury (DILI) are essential for the diagnosis of severe cases of DILI in clinical trials and clinical practice, but the currently used biomarker paradigm detects damage after it has occurred and has limited prognostic value. The development of new biomarker strategies that improve the diagnosis of DILI by providing increased specificity and/or by identifying individual patients who are at risk for DILI is therefore crucial.

引用

页数：3

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