Susceptibility of Actinomyces israelii to antibiotics, sodium hypochlorite and calcium hydroxide

被引：27

作者：

Barnard, D ^{[1
]}

Davies, J ^{[1
]}

Figdor, D ^{[1
]}

机构：

[1] MED CTR,MELBOURNE,VIC 3004,AUSTRALIA

来源：

INTERNATIONAL ENDODONTIC JOURNAL | 1996年 / 29卷 / 05期

关键词：

Actinomyces israelii; actinomycosis; antibiotic tolerance; calcium hydroxide; sodium hypochlorite;

D O I：

10.1111/j.1365-2591.1996.tb01392.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Actinomyces israelii has been repeatedly implicated as a cause of failure of endodontic therapy. This study investigated the antimicrobial effect of antibiotics as well as intracanal medicaments, sodium hypochlorite solution and calcium hydroxide, on this important pathogen. Growth of A. israelii, was inhibited by low concentrations of antibiotics, yet high concentrations were not bactericidal for A israelii over 1 week. When A. israelii was exposed for 2-6 weeks at concentrations equivalent to clinical serum levels, the antibiotics were lethal. The results reveal a species - specific antibiotic tolerance for A. israelii. both sodium hypochlorite solution and calcium hydroxide were found to be highly effective in killing A. israelii.

引用

页码：320 / 326

页数：7

共 55 条

[21] IMMUNOCYTOCHEMICAL DEMONSTRATION OF ACTINOMYCES SPECIES AND ARACHNIA-PROPIONICA IN PERIAPICAL INFECTIONS [J].