Polymer nanogels: A versatile nanoscopic drug delivery platform

被引：596

作者：

Chacko, Reuben T. ^{[1
]}

Ventura, Judy ^{[1
]}

Zhuang, Jiaming ^{[1
]}

Thayumanavan, S. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2012年 / 64卷 / 09期

关键词：

Nanomaterial; Ligand display; Encapsulation stability; Stimuli responsive; CROSS-LINKED NANOPARTICLES; MACROMOLECULAR THERAPEUTICS; BIODEGRADABLE NANOPARTICLES; CANCER-CHEMOTHERAPY; COPOLYMER MICELLES; PEGYLATED NANOGELS; TARGETED DELIVERY; CARBON NANOTUBES; TUMOR; RELEASE;

D O I：

10.1016/j.addr.2012.02.002

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an "ideal" drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：836 / 851

页数：16

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