Chemokines as Mediators of Neovascularization

被引：161

作者：

Keeley, Ellen C. ^{[2
]}

Mehrad, Borna ^{[3
]}

Strieter, Robert M. ^{[1
,3
]}

机构：

[1] Univ Virginia, Dept Med, Div Pulm Crit Care, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Med, Div Cardiol, Charlottesville, VA 22908 USA

[3] Univ Virginia, Dept Med, Div Pulm & Crit Care Med, Charlottesville, VA 22908 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2008年 / 28卷 / 11期

关键词：

angiogenesis; cytokines; arteriogenesis; chemokines;

D O I：

10.1161/ATVBAHA.108.162925

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation. Chemokines have since been recognized as key factors mediating both physiological and pathological neovascularization in such diverse clinical settings as malignancy, wound repair, chronic fibroproliferative disorders, myocardial ischemia, and atherosclerosis. Members of the CXC chemokine family, structurally defined as containing the ELR amino acid motif, are potent inducers of angiogenesis, whereas another subset of the CXC chemokines inhibits angiogenesis. In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization. (Arterioscler Thromb Vasc Biol. 2008;28:1928-1936)

引用

页码：1928 / 1936

页数：9

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