Two new natural products from the fruits of Alpinia oxyphylla with inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophage cells

被引：73

作者：

Qing, Zhang Jun ^{[1
,2
,3
,4
]}

Yong, Wang ^{[2
,3
,4
]}

Hui, Li Yong ^{[2
,3
,4
]}

Yong, Lai Wei ^{[2
,3
,4
]}

Long, Li Hai ^{[2
,3
,4
]}

Ao, Duan Jin ^{[1
]}

Xia, Pei Li ^{[5
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Jiangsu, Peoples R China

[2] Hainan Med Univ, Sch Pharmaceut Sci, Haikou 571199, Peoples R China

[3] Hainan Prov Key Lab R&D Trop Med Plants, Haikou 571199, Peoples R China

[4] Haikou Municipal Key Lab Li Nationality Med, Haikou 571199, Peoples R China

[5] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Pharmacol Lab Tradit Chinese Med, Shanghai 200032, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2012年 / 35卷 / 12期

关键词：

Zingerberaceae; Alpinia oxyphylla; Sesquiterpenoids; Structure elucidation; Antiinflammatory effects; CHEMICAL-CONSTITUENTS; SESQUITERPENES;

D O I：

10.1007/s12272-012-1211-7

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Chemical investigation of the fruits of Alpinia oxyphylla led to an isolation of the two new natural products, 9-hydroxy epinootkatol (1) and (S)-2-pentanol-2-O-beta-D-glucopyranoside (2), in addition to the nine known compounds, pinocembrin (3), tectochrysin (4), izalpinin (5), nookatone (6), yakuchinone A (7), protocatechuic acid (8), beta-sitosterol (9), daucosterol (10) and beta-sitosterol palmitate (11). Their structures were elucidated on the basis of physicochemical constants and NMR spectral data analysis. The effects of the isolated components on nitric oxide production in LPS-induced RAW 264.7 macrophages were examined. The two new natural compounds showed inhibitory activities with IC50 values of 21.8 and 32.8 mu g/mL, respectively.

引用

页码：2143 / 2146

页数：4

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