MULTI-COMPONENT QUANTITATION OF LORATADINE, PSEUDOEPHEDRINE AND PARACETAMOL IN PLASMA AND PHARMACEUTICAL FORMULATIONS WITH LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY UTILIZING A MONOLITHIC COLUMN

被引：16

作者：

Abro, Kamran ^{[1
,2
]}

Memon, Najma ^{[1
]}

Bhanger, M. I. ^{[1
]}

Perveen, Shahnaz ^{[2
]}

Kandhro, Aftab ^{[2
]}

机构：

[1] Univ Sindh Jamshoro, Natl Ctr Excellence Analyt Chem, Jamshoro 76080, Pakistan

[2] Pakistan Council Sci & Ind Res Labs Complex, Karachi 75280, Pakistan

来源：

QUIMICA NOVA | 2012年 / 35卷 / 10期

关键词：

antihistamines; decongestants; liquid chromatography-tandem MS; ELECTROSPRAY-IONIZATION; IN-VITRO; CHLORPHENIRAMINE;

D O I：

10.1590/S0100-40422012001000012

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The purpose of this study was to develop a rapid, simple and sensitive quantitation method for pseudoephedrine (PSE), paracetamol (PAR) and loratadine (LOR) in plasma and pharmaceuticals using liquid chromatography-tandem mass spectrometry with a monolithic column. Separation was achieved using a gradient composition of methanol-0.1% formic acid at a flow rate of 1.0 mL min(-1). Mass spectral transitions were recorded in SRM mode. System validation was evaluated for precision, specificity and linearity. Limit of detection for pseudoephediine, paracetamol, and loratadine were determined to be 3.14, 1.86 and 1.44 ng mL(-1) respectively, allowing easy determination in plasma with % recovery of 93.12 to 101.56%.

引用

收藏

页码：1950 / 1954

页数：5

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