Ribosomal dynamics explored by cryo-electron microscopy

被引：9

作者：

Frank, J ^{[1
]}

机构：

[1] Hlth Res Inc, Howard Hughes Med Inst, Wadsworth Ctr, Albany, NY 12201 USA

来源：

METHODS | 2001年 / 25卷 / 03期

关键词：

D O I：

10.1006/meth.2001.1243

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cryo-electron microscopy has furnished direct evidence for conformational changes of the ribosome as it proceeds, in a cyclic manner, through different functional states. Strategies to explore the ribosome dynamics include trapping of particular functionally meaningful states by chemical, genetic, or physical means. The new atomic information obtained by X-ray crystallography should make it possible to track conformational changes observed by cryo-electron microscopy to changes of the underlying structural framework of the ribosome. (C) 2001 Elsevier Science.

引用

页码：309 / 315

页数：7

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