DNA mismatch repair in mammals: Role in disease and meiosis

被引:36
作者
Arnheim, N [1 ]
Shibata, D [1 ]
机构
[1] UNIV SO CALIF,SCH MED,DEPT PATHOL,LOS ANGELES,CA 90033
关键词
D O I
10.1016/S0959-437X(97)80150-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The understanding of mammalian mismatch repair (MMR) gene function has been accelerated as a result of progress on several fronts. First, the biochemical analysis of MMR has been advanced by the production of purified human MMR proteins which will eventually allow reconstitution of MMR activity in vitro. Second, a wealth of clinical studies on colon cancer patients have begun to allow correlations to be made among MMR mutations, tumor types, therapeutic approaches and clinical outcomes. Finally, new unexpected meiotic phenotypes have been associated with mutations in certain mouse MMR genes.
引用
收藏
页码:364 / 370
页数:7
相关论文
共 93 条
  • [31] LOSS OF THE WILD-TYPE MLH1 GENE IS A FEATURE OF HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER
    HEMMINKI, A
    PELTOMAKI, P
    MECKLIN, JP
    JARVINEN, H
    SALOVAARA, R
    NYSTROMLAHTI, M
    DELACHAPELLE, A
    AALTONEN, LA
    [J]. NATURE GENETICS, 1994, 8 (04) : 405 - 410
  • [32] HONCHEL R, 1994, CANCER RES, V54, P1159
  • [33] APC mutations in colorectal tumors with mismatch repair deficiency
    Huang, J
    Papadopoulos, N
    McKinley, AJ
    Farrington, SM
    Curtis, LJ
    Wyllie, AH
    Zheng, S
    Willson, JKV
    Markowitz, SD
    Morin, P
    Kinzler, KW
    Vogelstein, B
    Dunlop, MG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (17) : 9049 - 9054
  • [34] HUNTER N, 1996, MOL CELL BIOL, V16, P6110
  • [35] UBIQUITOUS SOMATIC MUTATIONS IN SIMPLE REPEATED SEQUENCES REVEAL A NEW MECHANISM FOR COLONIC CARCINOGENESIS
    IONOV, Y
    PEINADO, MA
    MALKHOSYAN, S
    SHIBATA, D
    PERUCHO, M
    [J]. NATURE, 1993, 363 (6429) : 558 - 561
  • [36] GENETIC INSTABILITY ASSOCIATED WITH ADENOMA TO CARCINOMA PROGRESSION IN HEREDITARY NONPOLYPOSIS COLON-CANCER
    JACOBY, RF
    MARSHALL, DJ
    KAILAS, S
    SCHLACK, S
    HARMS, B
    LOVE, R
    [J]. GASTROENTEROLOGY, 1995, 109 (01) : 73 - 82
  • [37] Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability
    Johnson, RE
    Kovvali, GK
    Prakash, L
    Prakash, S
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) : 7285 - 7288
  • [38] Kane MF, 1997, CANCER RES, V57, P808
  • [39] KATABUCHI H, 1995, CANCER RES, V55, P5556
  • [40] KIM HG, 1994, AM J PATHOL, V145, P148