Key role of the dorsal root ganglion in neuropathic tactile hypersensibility

被引:113
作者
Sukhotinsky, I [1 ]
Ben-Dor, E [1 ]
Raber, P [1 ]
Devor, M [1 ]
机构
[1] Hebrew Univ Jerusalem, Inst Life Sci, Dept Cell & Anim Biol, IL-91904 Jerusalem, Israel
关键词
dorsal root ganglion; ectopic firing; indwelling catheter; neuropathic pain; rhizotomy;
D O I
10.1016/S1090-3801(03)00086-7
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Cutting spinal nerves just distal to the dorsal root ganglion (DRG) triggers, with rapid onset, massive spontaneous ectopic discharge in axotomized afferent A-neurons, and at the same time induces tactile allodynia in the partially denervated hindlimb. We show that secondary transection of the dorsal root (rhizotomy) of the axotomized DRG, or suppression of the ectopia with topically applied local anesthetics, eliminates or attenuates the allodynia. Dorsal rhizotomy alone does not trigger allodynia. These observations support the hypothesis that ectopic firing in DRG A-neurons induces central sensitization which leads to tactile allodynia. The question of how activity in afferent A-neurons, which are not normally nociceptive, might induce allodynia is discussed in light of the current literature. (C) 2003 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:135 / 143
页数:9
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