Where PI3K/Akt Meets Smads: The Crosstalk Determines Human Embryonic Stem Cell Fate

被引：61

作者：

Chen, Ye-Guang ^{[1
]}

Li, Zhongwei ^{[1
]}

Wang, Xiao-Fan ^{[2
]}

机构：

[1] Tsinghua Univ, Sch Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China

[2] Duke Univ, Dept Pharmacol & Canc Biol, Med Ctr, Durham, NC 27710 USA

来源：

CELL STEM CELL | 2012年 / 10卷 / 03期

关键词：

SELF-RENEWAL; MAINTENANCE; PLURIPOTENCY;

D O I：

10.1016/j.stem.2012.02.008

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Coordinated interactions between signaling networks govern the balance of cell fate decisions in human embryonic stem cells. In this issue, Singh et al. (2012) report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and prodifferentiation by regulating ERK and GSK3 beta/beta-catenin signaling.

引用

收藏

页码：231 / 232

页数：2

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