Extrinsic regulation of pluripotent stem cells

被引：222

作者：

Pera, Martin F. ^{[1
]}

Tam, Patrick P. L. ^{[2
,3
]}

机构：

[1] Univ So Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90033 USA

[2] Childrens Med Res Inst, Embryol Unit, Westmead, NSW 2145, Australia

[3] Univ Sydney, Sydney Med Sch, Discipline Med, Sydney, NSW 2006, Australia

来源：

NATURE | 2010年 / 465卷 / 7299期

关键词：

FIBROBLAST-GROWTH-FACTOR; SELF-RENEWAL; MAINTAINS PLURIPOTENCY; LINEAGE COMMITMENT; BMP INHIBITOR; GROUND-STATE; GERM-LINE; ES CELLS; DIFFERENTIATION; EXPRESSION;

D O I：

10.1038/nature09228

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show that cultured stem-cell lines derived from different stages of mouse development can mimic these transition states. They further reveal that there is a high degree of heterogeneity and plasticity in pluripotent populations in vitro and that these properties are modulated by extrinsic signalling. Understanding the extrinsic control of plasticity will guide efforts to use human pluripotent stem cells in research and therapy.

引用

页码：713 / 720

页数：8

共 97 条

[1] Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [J].

Adewumi, Oluseun ;

Aflatoonian, Behrouz ;

Ahrlund-Richter, Lars ;

Amit, Michal ;

Andrews, Peter W. ;

Beighton, Gemma ;

Bello, Paul A. ;

Benvenisty, Nissim ;

Berry, Lorraine S. ;

Bevan, Simon ;

Blum, Barak ;

Brooking, Justin ;

Chen, Kevin G. ;

Choo, Andre B. H. ;

Churchill, Gary A. ;

Corbel, Marie ;

Damjanov, Ivan ;

Draper, Jon S. ;

Dvorak, Petr ;

Emanuelsson, Katarina ;

Fleck, Roland A. ;

Ford, Angela ;

Gertow, Karin ;

Gertsenstein, Marina ;

Gokhale, Paul J. ;

Hamilton, Rebecca S. ;

Hampl, Ales ;

Healy, Lyn E. ;

Hovatta, Outi ;

Hyllner, Johan ;

Imreh, Marta P. ;

Itskovitz-Eldor, Joseph ;

Jackson, Jamie ;

Johnson, Jacqueline L. ;

Jones, Mark ;

Kee, Kehkooi ;

King, Benjamin L. ;

Knowles, Barbara B. ;

Lako, Majlinda ;

Lebrin, Franck ;

Mallon, Barbara S. ;

Manning, Daisy ;

Mayshar, Yoav ;

Mckay, Ronald D. G. ;

Michalska, Anna E. ;

Mikkola, Milla ;

Mileikovsky, Masha ;

Minger, Stephen L. ;

Moore, Harry D. ;

Mummery, Christine L. .

NATURE BIOTECHNOLOGY, 2007, 25 (07) :803-816

[2] Primary differentiation in the human blastocyst: Comparative molecular portraits of inner cell mass and trophectoderm cells [J].

Adjaye, J ;

Huntriss, J ;

Herwig, R ;

BenKahla, A ;

Brink, TC ;

Wierling, C ;

Hultschig, C ;

Groth, D ;

Yaspo, ML ;

Picton, HM ;

Gosden, RG ;

Lehrach, H .

STEM CELLS, 2005, 23 (10) :1514-1525

[3] Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture [J].

Amit, M ;

Carpenter, MK ;

Inokuma, MS ;

Chiu, CP ;

Harris, CP ;

Waknitz, MA ;

Itskovitz-Eldor, J ;

Thomson, JA .

DEVELOPMENTAL BIOLOGY, 2000, 227 (02) :271-278

[4] A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas [J].

Assou, Said ;

Le Carrour, Tanguy ;

Tondeur, Sylvie ;

Strom, Susanne ;

Gabelle, Audrey ;

Marty, Sophie ;

Nadal, Laure ;

Pantesco, Veronique ;

Reme, Thierry ;

Hugnot, Jean-Philippe ;

Gasca, Stephan ;

Hovatta, Outi ;

Hamamah, Samir ;

Klein, Bernard ;

De Vos, John .

STEM CELLS, 2007, 25 (04) :961-973

[5] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [J].

Babaie, Yasmin ;

Herwig, Ralf ;

Greber, Boris ;

Brink, Thore C. ;

Wruck, Wasco ;

Groth, Detlef ;

Lehrach, Hans ;

Burdon, Tom ;

Adjaye, James .

STEM CELLS, 2007, 25 (02) :500-510

[6] Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells [J].

Bao, Siqin ;

Tang, Fuchou ;

Li, Xihe ;

Hayashi, Katsuhiko ;

Gillich, Astrid ;

Lao, Kaiqin ;

Surani, M. Azim .

NATURE, 2009, 461 (7268) :1292-1295

[7] IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro [J].

Bendall, Sean C. ;

Stewart, Morag H. ;

Menendez, Pablo ;

George, Dustin ;

Vijayaragavan, Kausalia ;

Werbowetski-Ogilvie, Tamra ;

Ramos-Mejia, Veronica ;

Rouleau, Anne ;

Yang, Jiabi ;

Bosse, Marc ;

Lajoie, Gilles ;

Bhatia, Mickie .

NATURE, 2007, 448 (7157) :1015-U3

[8] Unraveling epigenetic regulation in embryonic stem cells [J].

Bibikova, Marina ;

Laurent, Louise C. ;

Ren, Bing ;

Loring, Jeanne F. ;

Fan, Jian-Bing .

CELL STEM CELL, 2008, 2 (02) :123-134

[9] Phosphoproteomic Analysis of Human Embryonic Stem Cells [J].

Brill, Laurence M. ;

Xiong, Wen ;

Lee, Ki-Bum ;

Ficarro, Scott B. ;

Crain, Andrew ;

Xu, Yue ;

Terskikh, Alexey ;

Snyder, Evan Y. ;

Ding, Sheng .

CELL STEM CELL, 2009, 5 (02) :204-213

[10] Derivation of pluripotent epiblast stem cells from mammalian embryos [J].

Brons, I. Gabrielle M. ;

Smithers, Lucy E. ;

Trotter, Matthew W. B. ;

Rugg-Gunn, Peter ;

Sun, Bowen ;

de Sousa Lopes, Susana M. Chuva ;

Howlett, Sarah K. ;

Clarkson, Amanda ;

Ahrlund-Richter, Lars ;

Pedersen, Roger A. ;

Vallier, Ludovic .

NATURE, 2007, 448 (7150) :191-U7

← 1 2 3 4 5 6 7 8 9 10 →