Protein kinases and protein phosphatases in prokaryotes: a genomic perspective

被引:163
作者
Kennelly, PJ [1 ]
机构
[1] Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA
关键词
protein phosphorylation; protein kinase; protein phosphatase; phylogeny;
D O I
10.1016/S0378-1097(01)00479-7
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
For many years, the regulation of protein structure and function by phosphorylation and dephosphorylation was considered a relatively recent invention that arose independently in each phylogenetic domain. Over time, however, incidents of apparent domain trespass involving the presence of 'eukaryotic' protein kinases or protein phosphatases in prokaryotic organisms were reported with increasing frequency. Today, genomics has provided the means to examine the phylogenetic distribution of 'eukaryotic' protein kinases and protein phosphatases in a comprehensive and systematic manner. The results or these genome searches challenge previous conceptions concerning the origins and evolution of this versatile regulatory mechanism. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1 / 8
页数:8
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