Association study of the p53-gene Pro72Arg polymorphism in schizophrenia

被引：16

作者：

Chiu, HJ

Wang, YC

Chen, JY

Hong, CJ

Tsai, SJ ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan

[3] Yu Li Vet Hosp, Sect Psychiat, Hualien, Taiwan

[4] Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan

来源：

PSYCHIATRY RESEARCH | 2001年 / 105卷 / 03期

关键词：

association study; P53 tumor-suppressor gene; polymorphism; schizophrenia;

D O I：

10.1016/S0165-1781(01)00328-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The p53 tumor-suppressor gene, encoding a phosphoprotein, is a key element in maintaining genomic stability and cell apoptosis. It is also implicated in nervous-system development. In order to examine the role of the p53 gene for the pathogenesis of schizophrenic disorders, patients (n = 155) and control subjects (n = 168) were genotyped for the p53-Pro72Arg polymorphism. The results demonstrated no association with schizophrenia and/or age of onset for this polymorphism. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：279 / 283

页数：5

共 18 条

[1] Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene? [J].