Nontoxic membrane-active antimicrobial arylamide oligomers

被引：210

作者：

Liu, DH ^{[1
]}

Choi, S ^{[1
]}

Chen, B ^{[1
]}

Doerksen, RJ ^{[1
]}

Clements, DJ ^{[1
]}

Winkler, JD ^{[1
]}

Klein, ML ^{[1
]}

DeGrado, WF ^{[1
]}

机构：

[1] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 09期

关键词：

amphiphiles; antimicrobial agents; aryl amides; oligomers; peptides;

D O I：

10.1002/anie.200352791

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cracking the case: Aryl amide oligomers with amphiphilic secondary structure were designed that attack bacteria by lysing their membranes. A variety of groups were appended to the lead compound to adjust its overall charge, hydrophobicity, and hydrophobic moment. An Arg-containing oligomer (see figure) was found to have good antimicrobial activity and low toxicity towards human erythrocytes.

引用

页码：1158 / 1162

页数：5

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