TGF-β downregulates the activating receptor NKG2D on NK cells and CD8+ T cells glioma patients

被引：257

作者：

Crane, Courtney A. ^{[1
]}

Han, Seunggu J. ^{[1
]}

Barry, Jeffery J. ^{[1
]}

Ahn, Brian J. ^{[1
]}

Lanier, Lewis L. ^{[2
,3
]}

Parsa, Andrew T. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

来源：

NEURO-ONCOLOGY | 2010年 / 12卷 / 01期

关键词：

GBM; immune escape NKG2D; NK cell; TGF-beta; IN-VIVO; IFN-GAMMA; TUMOR; EXPRESSION; GROWTH; IMMUNOSURVEILLANCE; CYTOTOXICITY; LIGAND; MICA;

D O I：

10.1093/neuonc/nop009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The activating receptor NKG2D, expressed by natural killer (NK) cells and CD8(+) T cells, has a role in the specific killing of transformed cells. We examined NKG2D expression In patients with glioblastoma multiforme and found that NKG2D was downregulated on NK cells and CD8(+) T cells. Expression of NKG2D on lymphocytes significantly increased following tumor resection and correlated with all increased ability to kill NKG2D ligand-positive tumor targets. Despite the presence of soluble NKG2D ligands in the sera of glioblastoma patients, NKG2D downregulation was primarily caused by tumor-derived tumor growth factor-beta, suggesting that blocking of this cytokine may have therapeutic benefit.

引用

页码：7 / 13

页数：7

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