Enzymatic cytosine deamination: Friend AND foe

被引：7

作者：

Kunkel, TA ^{[1
]}

Diaz, M ^{[1
]}

机构：

[1] NIEHS, Genet Mol Lab, Res Triangle Pk, NC 27709 USA

来源：

MOLECULAR CELL | 2002年 / 10卷 / 05期

关键词：

D O I：

10.1016/S1097-2765(02)00750-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AID and Apobec proteins have several, normally beneficial cellular functions. It has now been discovered that they act as DNA mutators in E. coli by deaminating cytosine in DNA. Thus, they may produce genome instability in mammals if not controlled.

引用

页码：962 / 963

页数：2