Brasiliquinones A, B and C, new benz[alpha]anthraquinone antibiotics from Nocardia brasiliensis .1. Producing strain, isolation and biological activities of the antibiotics

被引：25

作者：

Nemoto, A

Tanaka, Y

Karasaki, Y

Komaki, H

Yazawa, K

Mikami, Y

Tojo, T

Kadowaki, K

Tsuda, M

Kobayashi, J

机构：

[1] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHUO KU,CHIBA 260,JAPAN

[2] HIGETA SHOYU RES LAB,CHOSHI,CHIBA 288,JAPAN

[3] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 01期

关键词：

D O I：

10.7164/antibiotics.50.18

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New benz[a]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.

引用

页码：18 / 21

页数：4

共 15 条

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