Optimization of fast CE analyses of ecstasy derivatives by use of experimental designs

被引:23
作者
Varesio, E
Gauvrit, JY
Longeray, R
Lantéri, P
Veuthey, JL
机构
[1] Univ Geneva, Lab Chim Analyt Pharmaceut, CH-1211 Geneva 4, Switzerland
[2] Univ Lyon 1, Lab Chimiometrie, ESCPE Lyon, Villeurbanne, France
关键词
capillary electrophoresis; amphetamines; ecstasy; full-factorial design; central composite design;
D O I
10.1007/BF02490651
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The separation by capillary electrophoresis of five ecstasy derivatives has been evaluated by means of experimental designs. A full-factorial design and a central composite design were employed to optimize the experimental conditions for a fast separation. With a conventional capillary (62.5 cm length) analytes were separated in less than 8 min. When the capillary:length was reduced the analysis time decreased substantially. Comparisons were made between different procedures (e.g. working at a constant field or at constant voltage) and finally, a fast separation of five Ecstasy derivatives was achieved in 1 min.
引用
收藏
页码:195 / 201
页数:7
相关论文
共 31 条
  • [31] Central composite design in the chiral analysis of amphetamines by capillary electrophoresis
    Varesio, E
    Gauvrit, JY
    Longeray, R
    Lanteri, P
    Veuthey, JL
    [J]. ELECTROPHORESIS, 1997, 18 (06) : 931 - 937