共 31 条
Optimization of fast CE analyses of ecstasy derivatives by use of experimental designs
被引:23
作者:
Varesio, E
Gauvrit, JY
Longeray, R
Lantéri, P
Veuthey, JL
机构:
[1] Univ Geneva, Lab Chim Analyt Pharmaceut, CH-1211 Geneva 4, Switzerland
[2] Univ Lyon 1, Lab Chimiometrie, ESCPE Lyon, Villeurbanne, France
关键词:
capillary electrophoresis;
amphetamines;
ecstasy;
full-factorial design;
central composite design;
D O I:
10.1007/BF02490651
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
The separation by capillary electrophoresis of five ecstasy derivatives has been evaluated by means of experimental designs. A full-factorial design and a central composite design were employed to optimize the experimental conditions for a fast separation. With a conventional capillary (62.5 cm length) analytes were separated in less than 8 min. When the capillary:length was reduced the analysis time decreased substantially. Comparisons were made between different procedures (e.g. working at a constant field or at constant voltage) and finally, a fast separation of five Ecstasy derivatives was achieved in 1 min.
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页码:195 / 201
页数:7
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