AURORA KINASES: STRUCTURE, FUNCTIONS AND THEIR ASSOCIATION WITH CANCER

被引：84

作者：

Kollareddy, Madhu ^{[1
]}

Dzubak, Petr ^{[1
]}

Zheleva, Daniella ^{[2
]}

Hajduch, Marian ^{[1
]}

机构：

[1] Palacky Univ, Fac Med, Dept Pediat, Expt Med Lab, Olomouc 77520, Czech Republic

[2] Cyclacel Pharmaceut Inc, Dundee DD1 5JJ, Scotland

来源：

BIOMEDICAL PAPERS-OLOMOUC | 2008年 / 152卷 / 01期

关键词：

Aurora kinases; Serine; threonine; Spindle; Centrosomes; Cytoskeleton; Cytokinesis; Oncogenes;

D O I：

10.5507/bp.2008.004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Background: Aurora kinases are a recently discovered family of kinases ( A, B & C) consisting of highly conserved serine\threonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpoint pathway, function of centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases may lead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review we discuss the biology of these kinases: structure, function, regulation and association with cancer. Methods and Results: A literature search. Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expression can lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one of the most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven effectively on a wide range of tumor types. The clinical data are very encouraging and promising for development of novel class of structurally different Aurora kinase inhibitors. Hopefully the Aurora kinases will be potentially useful in drug targeted cancer treatment.

引用

页码：27 / 33

页数：7

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