Innate immunity and aging

被引：218

作者：

Gomez, Christian R. ^{[4
,6
]}

Nomellini, Vanessa ^{[2
,4
,5
]}

Faunce, Douglas E. ^{[3
]}

Kovacs, Elizabeth J. ^{[1
,2
,4
,5
]}

机构：

[1] Loyola Univ, Burn & Shock Trauma Inst, Dept Surg, Med Ctr, Maywood, IL 60153 USA

[2] Loyola Univ, Dept Cell Biol Neurobiol & Anat, Med Ctr, Maywood, IL 60153 USA

[3] Loyola Univ, Dept Microbiol & Immunol, Med Ctr, Maywood, IL 60153 USA

[4] Loyola Univ, Immunol & Aging Program, Med Ctr, Maywood, IL 60153 USA

[5] Loyola Univ, Stritch Sch Med, Med Ctr, Maywood, IL 60153 USA

[6] Univ Diego Portales, Fac Ciencias Salud, Santiago, Chile

来源：

EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 08期

基金：

美国国家卫生研究院;

关键词：

neutrophils; macrophages; NK; NK-T; mast cells; eosinophils; age;

D O I：

10.1016/j.exger.2008.05.016

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：718 / 728

页数：11

共 183 条

[1] Biology of dendritic cells in aging [J].

Agrawal, Anshu ;

Agrawal, Sudhanshu ;

Tay, Jia ;

Gupta, Sudhir .

JOURNAL OF CLINICAL IMMUNOLOGY, 2008, 28 (01) :14-20

[2]

ALBRIGHT JF, 2003, SENESCENCE NATURAL I, P61

[3] AGE-ASSOCIATED IMPAIRMENT OF MURINE NATURAL-KILLER ACTIVITY [J].

ALBRIGHT, JW ;

ALBRIGHT, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20) :6371-6375

[4] B cell development and receptor diversity during aging [J].

Allman, D ;

Miller, JP .

CURRENT OPINION IN IMMUNOLOGY, 2005, 17 (05) :463-467

[5] The aging of early B-cell precursors [J].

Allman, D ;

Miller, JP .

IMMUNOLOGICAL REVIEWS, 2005, 205 :18-29

[6] IMMUNOSENESCENCE AND MUCOSAL IMMUNITY - SIGNIFICANT EFFECTS OF OLD-AGE ON SECRETORY IGA CONCENTRATIONS AND INTRAEPITHELIAL LYMPHOCYTE COUNTS [J].

ARRANZ, E ;

OMAHONY, S ;

BARTON, JR ;

FERGUSON, A .

GUT, 1992, 33 (07) :882-886

[7] Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response [J].

Ashcroft, GS ;

Greenwell-Wild, T ;

Horan, MA ;

Wahl, SM ;

Ferguson, MWJ .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (04) :1137-1146

[8]

BARBUL A, 1995, OTOLARYNG CLIN N AM, V28, P955

[9] Regulation of myeloid development and function by colony stimulating factors [J].

Barreda, DR ;

Hanington, PC ;

Belosevic, M .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2004, 28 (05) :509-554

[10] The biology of NKT cells [J].

Bendelac, Albert ;

Savage, Paul B. ;

Teyton, Luc .

ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :297-336

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