BDNF as an anterophin; a novel neurotrophic relationship between brain neurons

被引：54

作者：

Nawa, H ^{[1
]}

Takei, N ^{[1
]}

机构：

[1] Niigata Univ, Brain Res Inst, Div Mol Neurobiol, Niigata 9518585, Japan

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 12期

关键词：

D O I：

10.1016/S0166-2236(00)01955-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies of the peripheral nervous system have led to the concept of target-derived neurotrophic support. Neurotrophic factors such as nerve growth factor are now known to act as retrograde trophic factors-retrophins-that are produced in the target cells and released to presynaptic neurons. However, using brain-derived neurotrophic factor (BDNF) tagged with green-fluorescent protein to monitor the subcellular dynamics of BDNF in neurites, Tsumoto and colleagues have provided persuasive visual evidence that BDNF can be released at the synapses of brain neurons in an activity-dependent manner to act on postsynaptic neurons. Accordingly, BDNF serves as an anterophin to regulate postsynaptic development and plasticity in the central nervous system.

引用

页码：683 / 684

页数：2