P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation

被引：68

作者：

Weisman, Gary A. ^{[1
,2
,3
]}

Camden, Jean M. ^{[1
,3
]}

Peterson, Troy S. ^{[2
,3
]}

Ajit, Deepa ^{[1
,3
]}

Woods, Lucas T. ^{[1
,3
]}

Erb, Laurie ^{[1
,3
]}

机构：

[1] Univ Missouri, Dept Biochem, Life Sci Ctr 540E, Columbia, MO 65211 USA

[2] Univ Missouri, Interdisciplinary Neurosci Program, Columbia, MO 65211 USA

[3] Univ Missouri, Christopher S Bond Life Sci Ctr, Columbia, MO 65211 USA

来源：

MOLECULAR NEUROBIOLOGY | 2012年 / 46卷 / 01期

关键词：

P2Y(2) receptor; P2X7; receptor; Neuroprotection; Neuroinflammation; AMYLOID-BETA-PEPTIDE; GROWTH-FACTOR RECEPTOR; TUMOR-NECROSIS-FACTOR; DORSAL-ROOT GANGLION; NONADRENERGIC INHIBITORY NERVES; TRANSFORMED MOUSE FIBROBLASTS; PURINERGIC P2X(7) RECEPTOR; PROTEIN-COUPLED RECEPTOR; MESSENGER-RNA EXPRESSION; FOCAL TYROSINE KINASE;

D O I：

10.1007/s12035-012-8263-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors. Activation of these receptors regulates a wide range of physiological and pathological processes. In this review, we present an overview of the current literature regarding P2X and P2Y receptors in the CNS with a focus on the contribution of P2X7 and P2Y(2) receptor-mediated responses to neuroinflammatory and neuroprotective mechanisms.

引用

收藏

页码：96 / 113

页数：18

相关论文

共 285 条

[1] International union of pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy [J].

Abbracchio, Maria P. ;

Burnstock, Geoffrey ;

Boeynaems, Jean-Marie ;

Barnard, Eric A. ;

Boyer, Jose L. ;

Kennedy, Charles ;

Knight, Gillian E. ;

Fumagalli, Marta ;

Gachet, Christian ;

Jacobson, Kenneth A. ;

Weisman, Gary A. .

PHARMACOLOGICAL REVIEWS, 2006, 58 (03) :281-341

[2] Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family [J].

Abbracchio, MP ;

Boeynaems, JM ;

Barnard, EA ;

Boyer, JL ;

Kennedy, C ;

Miras-Portugal, MT ;

King, BF ;

Gachet, C ;

Jacobson, KA ;

Weisman, GA ;

Burnstock, G .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (02) :52-55

[3] PURINOCEPTORS - ARE THERE FAMILIES OF P2X AND P2Y PURINOCEPTORS [J].

ABBRACCHIO, MP ;

BURNSTOCK, G .

PHARMACOLOGY & THERAPEUTICS, 1994, 64 (03) :445-475

[4] P2X7 receptor: Death or life? [J].

Adinolfi E. ;

Pizzirani C. ;

Idzko M. ;

Panther E. ;

Norgauer J. ;

Di Virgilio F. ;

Ferrari D. .

Purinergic Signalling, 2005, 1 (3) :219-227

[5] Oligodendrocytes express P2Y12 metabotropic receptor in adult rat brain [J].

Amadio, S. ;

Tramini, G. ;

Martorana, A. ;

Viscomi, M. T. ;

Sancesario, G. ;

Bernardi, G. ;

Volonte, C. .

NEUROSCIENCE, 2006, 141 (03) :1171-1180

[6] P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation [J].

Arthur, David B. ;

Akassoglou, Katerina ;

Insel, Paul A. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 347 (03) :678-682

[7] P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation [J].

Arthur, DB ;

Akassoglou, K ;

Insel, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (52) :19138-19143

[8] Inhibition of apoptosis by P2Y2 receptor activation:: Novel pathways for neuronal survival [J].

Arthur, DB ;

Georgi, S ;

Akassoglou, K ;

Insel, PA .

JOURNAL OF NEUROSCIENCE, 2006, 26 (14) :3798-3804

[9] A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases [J].

Arulkumaran, Nishkantha ;

Unwin, Robert J. ;

Tam, Frederick W. K. .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2011, 20 (07) :897-915

[10] Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit [J].

Ase, Ariel R. ;

Bernier, Louis-Philippe ;

Blais, Dominique ;

Pankratov, Yuriy ;

Seguela, Philippe .

JOURNAL OF NEUROCHEMISTRY, 2010, 113 (06) :1676-1684

← 1 2 3 4 5 6 7 8 9 10 →