Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family

被引：334

作者：

Abbracchio, MP

Boeynaems, JM

Barnard, EA

Boyer, JL

Kennedy, C

Miras-Portugal, MT

King, BF

Gachet, C

Jacobson, KA

Weisman, GA

Burnstock, G

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, London NW3 2PF, England

[2] Univ Complutense Madrid, Dept Bioquim, Madrid, Spain

[3] Univ Strathclyde, Dept Physiol & Pharmacol, Glasgow G1 1XQ, Lanark, Scotland

[4] Inspire Pharmaceut Inc, Mol Pharmacol, Durham, NC USA

[5] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England

[6] Free Univ Brussels, Erasme Hosp, IRIBHM, Brussels, Belgium

[7] Free Univ Brussels, Erasme Hosp, Dept Med Chem, Brussels, Belgium

[8] Univ Milan, Dept Pharmacol Sci, Milan, Italy

[9] EFS Alsace, INSERM U311, Strasbourg, France

[10] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD USA

[11] Univ Missouri, Dept Biochem, Columbia, MO USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 02期

关键词：

PROTEIN-COUPLED RECEPTOR; ADP RECEPTOR; IDENTIFICATION; PURINOCEPTORS; NUCLEOTIDES;

D O I：

10.1016/S0165-6147(02)00038-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently. This receptor has important structural similarities to known members of the P2Y receptor family but also shows a distinctly different pharmacological response profile. Here, the IUPHAR Subcommittee for P2Y receptor nomenclature and classification review the current knowledge of this receptor and present their reasons for including this receptor in the P2Y receptor family as the P2Y(14) receptor.

引用

页码：52 / 55

页数：4

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