Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding

被引：163

作者：

Xu, D. -X. ^{[1
]}

Densmore, A. ^{[1
]}

Delage, A. ^{[1
]}

Waldron, P. ^{[1
]}

McKinnon, R. ^{[1
]}

Janz, S. ^{[1
]}

Lapointe, J. ^{[1
]}

Lopinski, G. ^{[2
]}

Mischki, T. ^{[2
]}

Post, E. ^{[1
]}

Cheben, P. ^{[1
]}

Schmid, J. H. ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Microstruct Sci, Ottawa, ON K1A 0R6, Canada

[2] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON K1A 0R6, Canada

来源：

OPTICS EXPRESS | 2008年 / 16卷 / 19期

关键词：

D O I：

10.1364/OE.16.015137

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate folded waveguide ring resonators for biomolecular sensing. We show that extending the ring cavity length increases the resonator quality factor, and thereby enhances the sensor resolution and minimum level of detection, while at the same time relaxing the tolerance on the coupling conditions to provide stable and large resonance contrast. The folded spiral path geometry allows a 1.2 mm long ring waveguide to be enclosed in a 150 mu m diameter sensor area. The spiral cavity resonator is used to monitor the streptavidin protein binding with a detection limit of similar to 3 pg/mm(2), or a total mass of similar to 5 fg. The real time measurements are used to analyze the kinetics of biotin-streptavidin binding. (C) 2008 Optical Society of America.

引用

页码：15137 / 15148

页数：12

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