Highly stereoselective intermolecular oxy-Michael addition reaction to α,β-unsaturated malonate esters

被引：32

作者：

Buchanan, DJ ^{[1
]}

Dixon, DJ ^{[1
]}

Hernandez-Juan, FA ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol049820x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly diastereoselective oxy-Michael addition of the "naked" anion of (6S)-methyl delta lactol to alkylidiene-, arylidene-, and heteroarylidenemalonate derivatives leading to the direct formation of THP*-protected beta-hydroxy ester derivatives is described. Subsequent acid-mediated deprotection affords the enantioenriched aldol products in quantitative yields.

引用

页码：1357 / 1360

页数：4

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