Solid phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step

被引:80
作者
Kim, SW
Ahn, SY
Koh, JS
Lee, JH
Ro, S
Cho, HY
机构
[1] Biotech Research Institute, LG Chemical Ltd., Research Park Science Town
关键词
D O I
10.1016/S0040-4039(97)00986-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The variety of N,N-disubstituted hydantoin libraries were constructed using derivatives of amino acids, aromatic aldehydes, and isocyanates. The cyclization step of hydantoin was a novel, fast and clean reaction and completed within five minutes to 1 hour with near diisopropylamine. All library compounds were obtained in excellent yield with high purity even after 5 steps. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:4603 / 4606
页数:4
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