Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones

被引：62

作者：

Buckman, BO

Mohan, R

机构：

[1] New Lead Discovery, Berlex Biosciences, Richmond, CA 94804-0099

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 26期

关键词：

D O I：

10.1016/0040-4039(96)00878-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of 1,3-dialkyl quinazoline-2,4-diones 9 has been synthesized on polymeric support by a three step approach. Addition of isocyanates or amines to a polymer-supported anthranilate derivative affords urea 6 which can be cyclized to 3-alkyl quinazolinedione 7. N-Alkylation at the 1-position and cleavage from the resin affords 9a-o in high yield and purity. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：4439 / 4442

页数：4

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