A Supramolecular Peptide Synthesizer

被引：16

作者：

Bertran-Vicente, Jordi ^{[1
,2
]}

Hackenberger, Christian P. R. ^{[1
,2
]}

机构：

[1] Leibniz Inst Mol Pharmakol FMP, D-13125 Berlin, Germany

[2] Humboldt Univ, Dept Chem, D-12489 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 24期

关键词：

peptide synthesis; peptides; polypeptide biosynthesis; ribosomes; supramolecular chemistry; CHEMICAL LIGATION; PROTEINS;

D O I：

10.1002/anie.201301825

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Line up for synthesis! In a recent report the Leigh group described a rotaxane-based setup for the sequence-specific synthesis of small peptides, which runs automatically once started. This molecular machine combines elements from both chemical and biochemical peptide (bio-)syntheses, which are discussed in this Highlight. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6140 / 6142

页数：3

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