Chemoselective Ligation and Modification Strategies for Peptides and Proteins

被引：604

作者：

Hackenberger, Christian P. R. ^{[1
]}

Schwarzer, Dirk ^{[2
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[2] Leibniz Inst Mol Pharmakol FMP, D-13125 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 52期

关键词：

chemoselectivity; native chemical ligation; peptides; protein ligation; semisynthesis;

D O I：

10.1002/anie.200801313

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Selectivity is the key! Chemoselective ligation and modification strategies are important methods for linking synthetic or recombinant unprotected peptides to generate large polypeptides (see scheme). Recent developments in this research area have led to numerous applications in the semisynthesis and total synthesis of proteins. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：10030 / 10074

页数：45

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