Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions

被引：527

作者：

Angell, Yu L.

Burgess, Kevin

机构：

[1] Department of Chemistry, Texas A and M University, College Station, TX, 77841

来源：

CHEMICAL SOCIETY REVIEWS | 2007年 / 36卷 / 10期

关键词：

D O I：

10.1039/b701444a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This critical review concerns the impact of copper-mediated alkyne-azide cycloadditions on peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into peptide chains, to link peptides to other functionalities ( e. g. carbohydrates, polymers, and labels), and as a basis for evolution of less peptidic compounds as pharmaceutical leads. It will be of interest to those studying this click reaction, peptidomimetic secondary structure and function, and to medicinal chemists.

引用

页码：1674 / 1689

页数：16

共 73 条

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