CuI-catalyzed alkyne-azide "click" cycloadditions from a mechanistic and synthetic perspective

被引：1500

作者：

Bock, VD ^{[1
]}

Hiemstra, H ^{[1
]}

van Maarseveen, JH ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1018 WS Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 01期

关键词：

click chemistry; cycloaddition; heterocycles; molecular diversity; azides;

D O I：

10.1002/ejoc.200500483

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cu-I-catalyzed alkyne-azide cycloaddition provides 1,4-disubstituted 1,2,3-triazoles with such efficiency and scope that the transformation has been described as "click" chemistry. An overview of the mechanism of this remarkable reaction is presented as a means to explain the myriad of experimental results, particularly the various methods of catalyst generation, solvent and substrate effects, and choice of base or ligand. Both solution-phase and solid-phase results are comprehensively examined. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).

引用

页码：51 / 68

页数：18

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