A versatile synthesis of fused triazolo derivatives by sequential Ugi/alkyne-azide cycloaddition reactions

被引:118
作者
Akritopoulou-Zanze, I [1 ]
Gracias, V [1 ]
Djuric, SW [1 ]
机构
[1] Abbott Labs, Abbott Pk, IL 60064 USA
关键词
multi-component reactions; Ugi; intramolecular azide-alkyne cycloaddition; fused triazolo derivatives; dihydrotriazolo [1,5-a]pyrazinones; triazolobenzodiazepines; sequential Ugi/IAAC; fused heterocycles;
D O I
10.1016/j.tetlet.2004.09.117
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We report a facile synthesis of fused dihydrotriazolo[1,5-alpha]pyrazinones and triazolobenzodiazepines by an Ugi/alkyne-azide cycloaddition synthetic sequence. The coupling of the Ugi multi-component reaction with the intramolecular alkyne-azide cycloaddition provides access to highly functionalized heterocyclic ring systems in two steps from easily available starting materials in excellent overall yields. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:8439 / 8441
页数:3
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