Application of tandem Ugi reaction/ring-closing metathesis in multicomponent synthesis of unsaturated nine-membered lactams

被引：68

作者：

Banfi, L ^{[1
]}

Basso, A ^{[1
]}

Guanti, G ^{[1
]}

Riva, R ^{[1
]}

机构：

[1] Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 41期

关键词：

D O I：

10.1016/j.tetlet.2003.08.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new straightforward entry into unsaturated nine-membered lactams of potential use as external reverse turn inducers was developed. It is based on an Ugi multicomponent reaction using two unsaturated substrates, followed by highly stereoselective ring-closing metathesis (RCM). The synthesis of a nine-membered secondary lactam by RCM is reported for the first time. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7655 / 7658

页数：4

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