Small non-coding RNAs and genomic imprinting

被引：51

作者：

Royo, H.

Bortolin, M. -L.

Seitz, H.

Cavaille, J.

机构：

[1] CNRS, UMR 5099, LBME, IFR 109, FR-31062 Toulouse, France

[2] UMMS, Dept Biochem & Mol Pharmacol, Worcester, MA USA

来源：

CYTOGENETIC AND GENOME RESEARCH | 2006年 / 113卷 / 1-4期

关键词：

D O I：

10.1159/000090820

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Experimental and computer-assisted approaches have led to the identification of hundreds of imprinted small RNA genes, mainly clustered in two chromosomal domains (human 15q1 1 -> q13 and 14q32 loci). The genes are only detected in placental mammals and belong to the C/D RNA and microRNA gene families. These are small non-coding RNAs involved in RNA-guided post-transcriptional RNA modifications and RNA-mediated gene silencing, respectively. Here, we discuss their potential functions and report the identification of novel small RNA genes lying within (or nearby) known imprinted chromosomal domains. Copyright (c) 2006 S. Karger AG, Basel.

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收藏

页码：99 / 108

页数：10

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